She starred in five films in 2000: Reindeer Games, The Yards, The Legend of Bagger Vance, Men of Honor, and Sweet November and was briefly considered a new "It girl".
Theron has said of this period in her career that, "I kept finding myself in a place where directors would back me but studios didn't.
Ten-thousand pairs were given to destitute children, and a portion of the proceeds went to CTAOP.She publicly stated that she refused to get married until same sex marriage became legal in the United States, saying: "I don't want to get married because right now the institution of marriage feels very one-sided, and I want to live in a country where we all have equal rights.I realized I couldn't dance anymore, and I went into a major depression.My mom came over from South Africa and said, 'Either you figure out what to do next or you come home, because you can sulk in South Africa'.Larger roles in widely released Hollywood films followed, and her career expanded in the late 1990s with box-office successes like The Devil's Advocate (1997), Mighty Joe Young (1998), and The Cider House Rules (1999).
She also appeared on the cover of the May 1999 issue of Playboy magazine, in photos taken several years earlier when she was an unknown model; Theron unsuccessfully sued the magazine for publishing them without her consent.Theron received critical acclaim for her portrayal of serial killer Aileen Wuornos in Monster, for which she won the Academy Award, Silver Bear, Golden Globe Award, and Screen Actors Guild Award for Best Actress, among other accolades, becoming the first South African to win an Academy Award in a major acting category.She received Academy Award and Golden Globe Award nominations for her performance in the sexual harassment-themed drama North Country (2005), and a Golden Globe Award nomination for her performance in Jason Reitman's film Young Adult (2011).You can't do that part of the [character-creation] work when you're [in the middle of] making the film. In 2012, she starred in Ridley Scott's science fiction film Prometheus.In 2013, Vulture/NYMag named her the 68th Most Valuable Star in Hollywood saying: "We’re just happy that Theron can stay on the list in a year when she didn’t come out with anything …The Charlize Theron Africa Outreach Project (CTAOP) was created in 2007 by Theron, who the next year was named a UN Messenger of Peace, in an effort to support African youth in the fight against HIV/AIDS.